Concierge.com's insider take:
Little Iseo is perhaps the prettiest of all the lakes (if you ignore the quarry that mars part of the western shore). The small towns dotted along the coast have some modest landmarks worth exploring. You can knock them all off in a single day, including driving time. In Lovere, the Palazzo Taldini houses a gallery displaying works by Old Masters such as Jacopo Bellini, Tintoretto, and Tiepolo. The Santa Maria della Neve church in nearby Pisogne is filled with 16th-century frescoes by Romanino. The rocky terrain is best seen from the weirdly eroded pinnacle outside the town of Zone. If you're staying at I Due Roccoli, however, you'll have time to take a boat over to explore Monte Isola, a mountainous island rising from the middle of the lake with a half-dozen tiny fishing villages specked along its forested slopes.