Concierge.com's insider take:
Its fortunes as London's nightlife neighborhood have waxed and waned repeatedly over recent years, but you always seem to end up in Soho for one reason or another, mainly due to the great and plentiful restaurants, bars, clubs, and shops (Carnaby Street remains popular, despite the tourist hordes). Bordered by Oxford Street, Shaftesbury Avenue, Regent Street, and Charing Cross Road, Soho is home to London's Chinatown, a much-reduced red-light district (it peaked during the 1970s), and thriving gay bars and businesses centered around Old Compton Street. It's also home to the British film industry—production facilities are concentrated here—and the twin anchors of literary-media–luvvies life: the Groucho Club (45 Dean St., W1; 44-207-439-4685 ; www.thegrouchoclub.com) and Soho House (45 Greek St, W1; 44-207-734-5188; www.sohohouse.com). Both are strictly members-only—but wangle an invite if you can.