Tierra del Fuego and Cape Horn
Concierge.com's insider take:
Chile's Region XII, beginning around 49°S, includes the western half of Tierra del Fuego and hundreds of largely uninhabited islands running down the Pacific coast as far as Cape Horn (it's not technically within Patagonia). Hammered by near-constant westerly winds and frequent rain and snow, even in summer, the terrain is hostile but compelling. The community of Porvenir, with 5,000 inhabitants largely descended from Croatian gold prospectors, forms the largest human presence. As far as activities, hiking and glacier-climbing in the remote Cordillera Darwin range are growing in popularity among the hard-core contingent.