This 85-room garden oasis offers easy access to the Sacred Valley's highlights of Pisac, Chinchero, Moray, and Maras, as well as the usual rafting, horseback riding, and trekking. But if you want to stay put, there's plenty to keep you occupied, including the spa, with its extensive list of locally inspired treatments; the planetarium-observatory, complete with a resident astronomer; and the Inca food programs, where guests can try their hand at Andean cooking. There's cable TV in the rooms, and a business center with Internet access for guests who can't break their technological ties. The decor is kept simple but stylish in the rooms and suites, with whitewashed stone walls, beamed ceilings, and hardwood floors.

A fabled landmark of the park- and mansion-heavy San Isidro district (other storied local attractions include the ancient olive trees of the Parque el Olivar and the pre-Columbian tomb at Huallamarca), this hacienda-style 1920s hotel was completely refurbished in 1998. Hence the combination in the 78 huge guest rooms of old-world elegance (colonial artwork on loan from Museo Pedro de Osma, for example) and modern amenities, such as high-speed Internet access, at a surprisingly reasonable price. The Perroquet restaurant serves both international cuisine and traditional Peruvian dishes, with live music Friday and Saturday nights. Los Vitrales lobby bar serves a traditional tea on weekday afternoons. The 18-hole, par-72 Lima Golf Club is just across the street.

Born as the 16th-century seminary of San Antonio Abad (itself built on the site of a former Inca palace), the Monasterio is one of Peru's most gorgeous hotels. Because the original architecture has been largely preserved, no two of the 127 guestrooms are alike. They range in size from the monastic (these were monks' cells, after all) to the presidential, in the form of sprawling suites. But each is well-appointed, blending modern facilities with Spanish colonial (heavy wooden shutters that swing open to reveal the city's copious supply of cupolas). Most rooms can be oxygen-enriched for a small surcharge, to help low-altitude-dwelling lungs (you're at 11,600 feet here). Another comfort enhancer to consider: Any of the soaks on offer from the resident Bath Butler. One good choice is the Qeros Bath, which comes with a glass of coca sour, a Peruvian cigar, scented candles, and antistress bath salts.

Formerly (and still best) known as the Machu Picchu Pueblo Hotel, these 85 eco-luxe lodgings include whitewashed casitas and a butler-attended, terraced villa, all with terra-cotta floors, beamed ceilings, and colorful alpaca blankets. While the villa's private gardens, marble bathrooms, and open-air showers strengthen the case for booking this option, the best part of the hotel—no matter where you sleep—is what's outside: 12 acres of misty forest, 160-plus species of bird, endless butterflies, and one of the world's most extensive orchid collections. Though the ruins of Machu Picchu are clearly the main draw (a day's hike or 30-minute bus ride away), the neighborhood's other Incan superstars merit a visit (Wiñay Wayna is particularly gorgeous), as does the hotel's Unu spa. The Andean fusion food at Café Inkaterra is served with Vilcanota River views, but in the unlikely event that you need a change of scenery, take the quick, if rocky, walk to the restaurant- and bar-lined main drag of Aguas Calientes.

This sprightly newcomer might well steal the spotlight from the Hotel Monasterio, long the top luxury option in Macchu Picchu's gateway town. Cusco's architectural heritage of Incan stone walls topped with colonial white stucco is echoed in this sixteenth-century building on a square steps from the main plaza. With just 11 suites, La Casona has the intimacy of a private home, and the building's colonial charms come with smart modern touches such as iPod speakers. Inside, a grassy courtyard is surrounded by rooms on two levels. Owners Denise and Joe Koechlin have fussed over every antique- and craft-strewn square foot of the place, and exquisite pillars, retablos, and benches have been sourced from all over Peru. The excellent restaurant—don't leave without trying the quinoa pancakes—offers a good deal of Andean hospitality.

No longer the sole preserve of backpackers and climbers, the Peruvian Andes have recently been crowned with luxurious retreats like this remote Orient-Express outpost in Colca Canyon, which is twice as deep as the Grand Canyon. It's tough to access (a three-hour drive from the nearest airport, in Arequipa) but worth the detour. While other area hotels are lavishly refurbished colonial villas, this one goes native. Twenty discrete chalets sit halfway up the canyon, sharing the altitude with soaring condors. Rooms, furnished in earthy colors with a pastoral polish, are supremely yet simply comfortable: a terra-cotta bowl of corn cobs, a vase of wild grasses, a panier of logs. Nights can be chilly at 9,800 feet above sea level, so you'll find wood-burning fireplaces, heated laja-stone floors, and piping-hot plunge pools on the private terraces. Staff slip a woolen hot water bottle between the bedsheets in the evening. Adventure here is the alpaca-soft sort, with eager-to-please local guides, support vehicles (carrying oxygen), and gourmet picnic meals. Or just look up and wish upon a shooting star in the gin-clear southern sky. The remote setting ensures glimpses of traditional Quechuan life, with the men embroidering and the women working the land, and the organic garden means fresh ingredients for local dishes like quinoa soup, stuffed peppers, and grilled guinea pig.

Once a rustic, government-run establishment, the Sanctuary Lodge was leased by Orient-Express in 1999 and transformed into an haute (if slightly cramped) eco-resort where organic Andean food is served on fine china and high tea takes place in native-plant gardens. The 31 comfortable rooms and suites are decorated in a traditional manner in pale shades and dark woods. But tangible luxuries are secondary here: The Sanctuary Lodge remains the lone hotel permitted to operate adjacent to the ruins (it's a five-minute walk from the entrance). You can roll out of bed and still beat the crowds to the citadel. For a taste of what awaits you, request a room with a view of Huayna Picchu (the peak that adorns every Machu Picchu postcard), though the jungle, river, and garden views are lovely, too. Reserve a year in advance if your trip coincides with the dry season (April through October), and six months in advance during the rest of the year.

Presiding over a quiet stretch of the Malecón (jetty) de la Reserva, Miraflores Park has some of the city's best seascapes—particularly from the rooftop pool and Observatory restaurant. Given this positioning, many of the hotel's 81 rooms and suites (all spacious and well equipped for business travelers) come with a bonus: Periodic paragliding fly-bys on view from your room. For additional destressing, head to the resident Zest spa. The lobby-side Poissonerie restaurant dishes up fresh, creative Peruvian-European cuisine.

The comfort seeker's alternative to the tents and sleeping bags of the standard Inca Trail, the four lodges that make up this trekking circuit allow weary bodies to recuperate nightly with hot tubs, down bedding, and (upon request) a massage therapist's hands. The lodges are scattered along the Salkantay route (higher and longer than the usual trek, this trail requires serious training), with views of the beautiful Salkantay peak.

While jungle settings aren't traditionally synonymous with creature comforts, Reserva Amazonica is a notable exception. Located near the Tambopata National Reserve in the Peruvian Amazon's Madre de Dios region, the lodge offers as much eco (canopy tours, birding excursions, native farming demonstrations) as resort (plunge pools, spa treatments, tropical drinks). To reach this private reserve and its 30 thatch-roof, lantern-lit, hammock-slung cabanas, fly into Puerto Maldonado, then take a one-hour boat ride on the Madre de Dios River.

While the standard "Gringo Trail" of Peru winds through the bucolic Sacred Valley of the Incas—typically in the form of a half-day speed tour of the area's greatest hits (ruins, salt flats, artisans' markets)—Inkaterra (a company that specializes in sustainable tourism in Peru) allows you to take it all in at your leisure. Surrounded by traditional indigenous communities, Inkaterra's five villas, with terra-cotta roofs and hardwood floors, offer a steady supply of local flavor in a luxurious context (think private cook, housekeeping, and guides). Explore the area on foot, horseback, or raft, then unwind in the tub with an eco-friendly terra-cotta exfoliant, aromatherapy candles, and Peruvian wine.