With the latest branch of the Hotel du Vin chain, this genteel riverside town, famous for its regatta, can claim one of the most alluring long-weekend hotels in England. In a first-rate example of industrial recycling, the former Brakspears Brewery has been imaginatively converted, with each of the 43 rooms named for a vineyard. All are done up with toast-colored walls and thick wall-to-wall carpeting, and furnished with solid oak pieces that have a Shaker simplicity. Plump duvets and Egyptian cotton sheets make for dreamboat beds, while baths have oversized cast-iron Victorian tubs. With thoughtful details—an electric kettle to make your own tea or coffee, organic toiletries, and DVD/CD players—these rooms are ideal for holing up with a good book. If the Champagne Bar and billiards room downstairs sound tempting, the Bistro suffers from cheeky Fawlty Towers service, so you're better off dining out.
When to go: April through June.
Which room to book: Spring for a Studio (doubles, $200–$297).