This eighteenth-century residence in Florence's trendy Santa Croce neighborhood has been deftly converted into an upscale 24-room hotel with a contemporary flair. The palatial music room, with its delicate frescoes and stuccoes, has minimalist black leather armchairs and couches. Guest rooms, a blend of comfort and high-tech conveniences, are similarly furnished and are outfitted with dressing areas and classic writing desks. Staff are attentive but informal, seducing guests with hospitable gestures such as a welcome drink, afternoon tea, and fine cigars in the smoking room.
When to go: Avoid August (it's hot and full of tourists) and January (cold and damp).
Which room to book: No. 308, for its terrace and view of the Basilica of Santa Croce (doubles, $552–$589).