Crickets buzz and owls hoot around the clock at northern Patagonia's Valle Perdido, a working winery with a hotel and spa. Muted interiors of dark wood and sand-colored concrete decorated with sprays of pampas grass echo the stony steppe outside. Staff explain just why antioxidant-rich polyphenols in grapes slow the skin's aging process, and employ them in exfoliation, facial, and bath treatments and the signature 90-minute body wraps, combined with honey, mud, or seaweed. Rose hips are used in a cell-nourishing facial wrap, while a chocolate-based tightening mask softens expression lines. Afterward, snack on smoked wild boar, rinse off under a Vichy shower, or simply gaze from the indoor-outdoor pool at fork-tailed flycatchers cavorting on 570 acres of poplar-ringed vineyards.