Concierge.com's insider take:
One of the last great antiques hubs in Europe, this long street, aptly running straight to the Rijksmuseum, is a legacy of the Golden Age when Holland's traders traversed the globe and returned laden with goods. Nieuwe Spiegelstraat is lined with arcane shops, each with its own cabinet of curiosities. At Decorativa, the specialty is museum-worthy 17th- and 18th-century portraits (9A N. Spiegelstraat; 31-20-320-1093). E.H. Ariëns Kappers deals in antique Dutch prints, including hard-to-find winter scenes of skaters skimming down Amsterdam's canals, as well as smaller, more moderately priced folk prints, which prove that bargains are sometimes still to be had along the antiques row (32 N. Spiegelstraat; 31-20-623-5356; www.masterprints.nl). And just off Nieuwe Spiegelstraat, on Keizersgracht, Thom & Lenny Nelis Antiques holds a collection of pharmaceutical objects, including apothecary jars and a dinosaur-sized plaster tooth that once hung over a dental office (541 Keizersgracht; 31-20-623-1546; www.nelisantiques.com).