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Concierge.com's insider take:
Leave it to modern-day Eastern Europe to create this low-rent shrine to '70s New York hedonism. One of the city's only true after-hours clubs, this Saturday-Sunday underground lounge between Masarykovo and Hlavni, the two downtown train stations, kicks off at 5 a.m. and keeps the beats pumping until it's time to crash at three in the afternoon. Night owls of various species end up here, some just before going to work, some after pulling another graveyard shift, and though the crowd is young, Czech, and extremely self-obsessed, strangers will fit in just fine, as long as they keep moving—and drinking. Obscure disco and house classics from a handful of resident DJs help maintain the buzz, and special events in coordination with other venues make Studio 54 a favorite party spot for the city's Peter Pan generation.
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