Ansonborough Inn, Charleston, South Carolina $$$$
Concierge.com's insider take:
Rustic-cum-nautical décor and huge rooms, big enough to house an entire family, set this all-suite B&B apart from the historic district's lace-and-doily crowd. Lord Anson of England, a master sailor, won the property in a spirited poker game with famous Charlestonian Thomas Gadsden. The inn now sports exposed brick, pine beams, wood ceilings, and clubby leather chairs. Each of the 37 units is unique; some have lofts with separate sleeping areas, five have fireplaces. All are decked out in faux antique furniture, original art, and warm fabrics. Wine and cheese is served on the rooftop terrace against a backdrop of the city's skyline. An authentic British pub pours pints, spirits, and wine. And the South Carolina Aquarium is just a short walk away.