Concierge.com's insider take:
Assisi, the most tourist-oriented town in Umbria, is also one of the hardest to find good accommodations in. The problem is that with guaranteed year-round turnover, the hoteliers of Saint Francis's hometown have little incentive to make an extra effort. San Crispino, however, is a refreshing exception. Not far from the church of Santa Chiara, the mansion that houses the residenza dates back to the Middle Ages, and its seven vaulted suites are inspired by themes from Saint Francis's Canticle of the Creatures: Sora Luna e Stelle ("Sister Moon and Stars") has a starry night sky frescoed on the ceiling, while Frate Foco ("Brother Fire") and Frate Sole ("Brother Sun"—the largest suite, with two double bedrooms) both have working fireplaces. San Crispino is part of the Assisi Wellness group, which also includes the San Crispino Resort and Spa and two country villas, one with a large pool. Spa treatments and wellness programs (including the intriguing-sounding "chocolate therapy") can be arranged at reception.